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BMS-470539 dihydrochloride
CAS No. 2341796-82-3
BMS-470539 dihydrochloride( —— )
Catalog No. M32812 CAS No. 2341796-82-3
BMS-470539 dihydrochloride is a selective and highly potent melanocortin 1 receptor (MC-1 R) agonist with anti-inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | Get Quote |
|
| 5MG | 117 | Get Quote |
|
| 10MG | 188 | Get Quote |
|
| 25MG | 419 | Get Quote |
|
| 50MG | 685 | Get Quote |
|
| 100MG | 1062 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMS-470539 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-470539 dihydrochloride is a selective and highly potent melanocortin 1 receptor (MC-1 R) agonist with anti-inflammatory activity.
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DescriptionBMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC50 of 120 nM, an EC50 of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties.
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In Vitro——
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In VivoAnimal Model:Wild-type (WT) and MC1 receptor recessive e/e mice induced with ischaemia-reperfusion Dosage:2.05 mg/kg, 6.16 mg/kg and 18.47 mg/kg Administration:Intravenous injection; for 125 minutes Result:Inhibited cell adhesion and emigration with no effect on cell rolling. Inhibited tissue expression of both CXCL1 and CCL2.
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Synonyms——
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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RecptorMelanocortin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2341796-82-3
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Formula Weight632.62
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Molecular FormulaC32H43Cl2N5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 125 mg/mL (197.59 mM ) H2O : ≥ 100 mg/mL (158.07 mM)
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SMILESCCCC(C1(C2=CC=CC=C2)CCN(CC1)C([C@H](NC([C@@H](N)CC3=CN=CN3C)=O)CC4=CC=C(C=C4)OC)=O)=O.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Herpin TF, et al. Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J Med Chem. 2003 Mar 27;46(7):1123-6.?
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